Watershed – Optimized Crystal Harvesting

Prevent loss or damage to the crystals that you’ve spent time growing and optimizing. The Watershed™ system protects drops from drying out during crystals harvesting, ensuring you obtain the best possible diffraction quality. Precisely control the humidity around your crystallization drops whenever you are harvesting crystals.

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Product Information

Simplify your crystal mounting

Watershed™ will simplify your crystal mounting allowing you to get the best possible diffraction which in turn allows you to optimize your crystal harvesting and post-growth treatment protocols. Additional benefits of using Watershed™ are:

  • Increase drop working times and prevent dried out drops
  • Reduce protein precipitation and degradation
  • Harvest more crystals from each drop
  • Reduce crystal non-isomorphism
  • Used controlled dehydration to improve diffraction
  • Use with cover slips, glass slides, crystallization plates, or your home X-ray source

Controlled Humidity Environment

Watershed™ provides a controlled humidity environment for a wide range of common sample preparation tasks, including:

  • Separating crystals from each other, from precipitate, and from protein skins that may form over crystallization drops
  • Soaking crystals in solutions containing cryoprotectants, heavy atoms or ligands
  • Harvesting crystals from drops onto X-ray sample mounts
  • Blotting or wicking away excess liquid from crystals to reduce background X-ray scatter and increase sample cooling rates during plunge cooling
  • Placing crystals in MiTeGen’s MicroRT capillaries or glass capillaries for room temperature data collection
  • Adjusting the hydration of crystals to a desired relative humidity, which may be different from their as-grown relative humidity, to modify protein structure or optimize diffraction properties

Watershed is already used at several facilities

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