MiTeGenBEAMLINE SPOTLIGHT
MX2 Beamline at LNLS in Brazil
An Experimental Station Dedicated to Macromolecular Crystallography
(Image of the MX2 Beamline Endstation.)
The MX2 beamline is an experimental station dedicated to Macromolecular Crystallography in the hard x-rays energy range (5 to 15 keV) with maximum flux at 8.5 keV. The station is available for conventional single wavelength data collection as well as for Single and Multiple-wavelength Anomalous Diffraction (SAD/MAD) experiments. MX2 operates on a 2.0 T hybrid 30-pole wiggler and its optical layout includes collimating mirror, Si(111) double-crystal monochromator and toroidal bendable mirror. The beamline is equipped with PILATUS2M detector from Dectris.
(by Dr Ana Carolina de Mattos Zeri, MX2, LNLS)
2017 CATALOG NOW AVAILABLE
FRAG XTAL SCREEN
Easy fragment-based lead discovery by crystallographic screening
A major challenge in drug discovery is the identification of chemical moieties that specifically interact with a particular protein target. Traditionally, this was addressed by High Throughput Screening (HTS) however, recently “Fragment Screening” has become increasingly popular.
Fragment-based lead discovery takes advantage of fragment evolution and linking. Small individual fragments with inherently low affinity but high efficiency are grown according to the structural model. The efficient binding of the fragments results in a nanomolar lead structure.
The Frag Xtal Screen offers an easy entry to fragment-based lead discovery (FBLD) by crystallographic screening
CRYSTALLOGRAPHY NEWS
Conformational variation of proteins at room temperature is not dominated by radiation damage
Russi, S., Gonzalez, A., Kenner, L. R., Keedy, D. A., Fraser, J. S. & van den Bedem, H. (2017). J. Synchrotron Rad. 24, 73-82.
X-ray radiation damage to biological macromolecules: further insights
Garman, E. F. & Weik, M. (2017). J. Synchrotron Rad. 24, 1-6.
UNIVERSAL PUCK STARTER KITS
Get all the tools you need to ship crystals to the synchrotron
The Universal V1-Puck (Unipuck) is the most widely accepted hardware for automated samples mounting systems at synchrotrons worldwide.
UPCOMING MEETING: WCPCW 2017
Register Now for the 2017 West Coast Protein Crystallography Workshop
We are excited to be attending this year’s West Coast Protein Crystallography Workshop being held at the Asilomar Conference Grounds in Pacific Grove, California (sure beats the winters in Ithaca, NY!). Stop by our table to get your copy of the 2017 Crystallography Catalog and learn about how our products are helping to explore the future of structural bioogy.
MICROTOOLS STARTER KITS
Get up–and–running with the right tools for your crystals
MiTeGen MicroTools™ help manipulate, measure, and prepare your crystals. They are rigid enough for precision, yet flexible enough to prevent damage to your crystals.
- (20) Individual MicroTools on 25 mm rods, preloaded into reusable magnetic bases
- (1) Magnetic Push-button Wand (for easily switching between tools)
- (1) Serrated-end tweezers
- (1) Holder and case
- (1) Tool location placard
Have an idea for a new tool or product, need us to answer a question, or have a comment on our existing products?